Microfluidics projects

Microfluidics projects

Single-cell array

Cellular heterogeneity is key principle in biology that can be linked to individual health status of humans. To investigate the ratio of early, normal and late as well as non-responding cells following exposure to chemicals, nanomaterials and bioactive substances, we are developing a single-cell microfluidic platform.

Partners:

 

Funding:
FFG NexGenUpCon

Multi-cellular spheroid array

The aim of the project is the generation of multi-cellular spheroids inside microfluidic devices to assess drug diffusivity.

Nanotox platform

We are currently developing a microfluidic live cell microarray containing integrated optical microsensors to continuously and non-invasively monitor oxygen consumption and acidification rates of various cell types in the absence and presence of nanoparticles.

Partners:

 

Funding:
FFG NexGenUpCon

Microfluidic wound healing & migration assay

All cell migration and wound healing assays are based on the inherent ability of adherent cells to move into adjacent cell-free areas, thus providing information on cell culture viability, cellular mechanisms and multicellular movements. We have developed a lab-on-a-chip capable of mechanically inducing circular cell-free areas within confluent cell layers.

Functional materials for microfluidic cell cultures

We have developed a novel method for cell cultivation in a micro-sized polymer device under anoxic (absence of oxygen) conditions, where neither additional supplements (oxygen scavengers) nor gas supply is needed.
The dissolved oxygen is scavenged by a modified thiol-ene-epoxy polymer, while the scavenging rate is adjustable by fabrication process and channel geometry.

Partners:

Blood cell phenotyping

We have established a multifunctional nanobiointerface inside microfluidic devices for selective blood cell capture, enrichment and phenotyping applications that features both excellent antifouling properties and high antibody activity.

Partners: