Monthly Archives: May 2020

Osteoarthritis model

  • 5:55PM May 04, 2020
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The aim of this project is to integrate a living tissue analogue that resembles the inner lining of a joint capsule into our complementary cell chip system. Called “synovial organ-on-a-chip”, this lab-on-a-chip will be used to study the destructive inflammatory process of rheumatoid synovitis by investigating the dynamic structural changes of the organ model.

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Rheumatic arthritis model

  • 5:54PM May 04, 2020
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The aim of this project is to integrate a living tissue analogue that resembles the inner lining of a joint capsule into our complementary cell chip system. Called “synovial organ-on-a-chip”, this lab-on-a-chip will be used to study the destructive inflammatory process of rheumatoid synovitis by investigating the dynamic structural changes of the organ model.

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desease model parkinson's

Parkinson’s model

  • 5:53PM May 04, 2020
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One of the main limitations in neuroscience and in the modeling of neurodegenerative diseases is the lack of advanced experimental in vitro models that truly recapitulate the complexity of the human brain. Therefore, it is the aim of the here proposed research project to generate brain-like organoids that resemble the human midbrain and their integration […]

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Stomach-on-a-chip

  • 4:51PM May 04, 2020
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In a collaborative project, we are supporting Dr. Carla Olivera’s Expression Regulation in Cancer Group at i3s Portugal (www.i3s.up.pt) in the development of a biomimetic stomach model.

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Placenta-on-a-chip

  • 4:50PM May 04, 2020
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The aim of the project is to recapitulate the physiological functions of the human placental barrier to study the adverse effects of high blood pressure on barrier function during pregnancies.

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Lung-on-a-chip

  • 4:49PM May 04, 2020
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The aim of this project is to develop biomimetic lung-model on chip to evaluate the toxicity of nanoparticles on healthy and compromised lungs.

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Cell barriers

  • 4:47PM May 04, 2020
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Three multi-layered membrane-based and sensor integrated microfluidic biochips are currently developed to study uptake transport properties of three biological barriers including the placenta, stomach, kidney and lung.

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Blood cell phenotyping

  • 4:43PM May 04, 2020
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We have established a multifunctional nanobiointerface inside microfluidic devices for selective blood cell capture, enrichment and phenotyping applications that features both excellent antifouling properties and high antibody activity.

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Functional materials for microfluidic cell cultures

  • 4:41PM May 04, 2020
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We have developed a novel method for cell cultivation in a micro-sized polymer device under anoxic (absence of oxygen) conditions, where neither additional supplements (oxygen scavengers) nor gas supply is needed. The dissolved oxygen is scavenged by a modified thiol-ene-epoxy polymer, while the scavenging rate is adjustable by fabrication process and channel geometry.

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